Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42-34.

Can we finally start Tony Pollard.

Ryan Tannehill ran and threw for touchdowns as the Tennessee Titans held off the New Orleans Saints 23-21 on Sunday for their NFL-best sixth straight victory.

Jameis Winston passed for touchdowns of 43 and 29 yards to Marquez Callaway, and the New Orleans Saints defeated the Jacksonville Jaguars 23-21 in a preseason game.

Let’s start with:PAYTON’S PLANOn Christmas night, Saints running back Alvin Kamara tied a 91-year-old NFL record by rushing for six touchdowns in a 52-33 wipeout of the Minnesota Vikings. “I was thinking about our best play there,” Payton explained afterward. Payton wasn’t talking about Nevers’ record six TD runs. “A lot of these players — I’d say most of these players — have no idea how good Gale Sayers was,” said Payton. “It was a great moment.”Brees said Payton mentioned Sayers’ mark before the Saints’ last touchdown drive.

Brees was 26 of 32 passing, including first-half TD throws of 14 yards to Tre’Quan Smith, 8 yards to Adam Trautman and 12 yards to Sanders, who missed the previous two games while on the COVID-19 list. Brees regained the league career TD pass lead with 654, three more than the 43-year-old Brady, who had thrown for 17 touchdowns and just one interception over his previous six games. The Saints intercepted Brady twice in a 34-23 season-opening win, with Janoris Jenkins returning one for a TD. Jared Cook fumbled at the Bucs 2 with the Saints looking to build on an early 7-0 lead. The Saints outgained the Bucs 241 yards to 36 up to that point.