Patrick Mahomes saw his first extended action of the preseason, throwing for 105 yards and a touchdown, and the Kansas City Chiefs beat the Arizona Cardinals 38-10 on Saturday night in the second preseason game for both teams.

Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by beating the Arizona Cardinals 38-10 in Mexico City.

The NFL’s handling of concussions has evolved dramatically from the days when players were given smelling salts on the bench and sent back into the game.

Dolphins quarterback Tua Tagovailoa suffered a second frightening injury in five days when he was carted off the field Thursday, and many want to know why he was playing at all.

Let the dealing begin — if mostly unofficial.

Kyler Murray had a shaky performance and that helped the Detroit Lions stun the Arizona Cardinals 30-12 on Sunday.

The Arizona Cardinals, playing once again without starting quarterback Kyler Murray and star wide receiver DeAndre Hopkins, returned to the top spot of the latest AP Pro32 poll.

Colt McCoy was outstanding filling in for Kyler Murray, throwing for 328 yards and two touchdowns, and the Arizona Cardinals beat the Seattle Seahawks 23-13.

Reigning Defensive Rookie of the Year Chase Young suffered a potentially serious right knee injury, putting a damper on Washington’s big win against Tom Brady and the Tampa Bay Buccaneers.

Cam Newton provided a flashback to his Superman days in his second debut with the Panthers He threw for one touchdown, ran for another and sparked Carolina to a 34-10 win over the Arizona Cardinals.

Despite being short-handed, the Arizona Cardinals returned to the top of the AP Pro32 poll after beating the San Francisco 49ers without quarterback Kyler Murray and wide receiver DeAndre Hopkins.

James Conner ran for two touchdowns and caught a 45-yard TD pass from backup quarterback Colt McCoy as the short-handed Arizona Cardinals beat the San Francisco 49ers 31-17.

Chad Henne and rookie Shane Buechele threw touchdown passes to help the Kansas City Chiefs beat the Arizona Cardinals 17-10 in a preseason game Friday night.

Matt Prater kicked two field goals in the final two minutes, including a 47-yard game winner with no time remaining, to lift the Arizona Cardinals over the Dallas Cowboys 19-16 on Friday night in a preseason game.

May is Skin Cancer Awareness Month, a time to stress the importance of annual skin checks and daily protection to save lives.

They're thinking much bigger than all that after a dominant 20-6 win over the New York Giants on Sunday night. The victory got the Browns closer to clinching their first playoff spot since 2002, the NFL’s longest drought. New York's opening drive stalled at the 8 after McCoy's throw to Evan Engram fell incomplete in the end zone. It could've worked, too: Kicker Graham Gano was wide open in the end zone. The Browns came right back with a scoring drive capped by Mayfield's 2-yard pass to a wide-open Hooper in the back of the end zone early in the second quarter.

Coupled with Tampa Bay’s 26-14 win over Minnesota (6-7), the Cardinals are back in a wild-card berth. we have to go out there and execute,” said Murray, who ran 10 times for 47 yards. “I don’t think we have any kind of a hangover from going out to Seattle last week," Giants coach Joe Judge said. The D limited New York to 159 yards in making Jones' return from a one-game absence with a hamstring injury miserable. The first one was set up by a 24-yard punt return by Christian Kirk to the Giants 38.

New York Giants defensive end Leonard Williams (99) celebrates with linebacker Tae Crowder (48) after Williams sacked Seattle Seahawks quarterback Russell Wilson (not shown) during the second half of an NFL football game, Sunday, Dec. 6, 2020, in Seattle. A fourth-and-18 desperation throw by Wilson was batted down, and the Giants were left to celebrate. “I’m really surprised that this is how we looked against this game plan that they had,” Seattle coach Pete Carroll said. SEATTLE’S WEIRD SCORESNot surprisingly, Seattle was involved in a game that had a strange score at some point. The 5-0 halftime score was the first in an NFL game since Week 2 of the 2013 season when the Seahawks led the 49ers 5-0 at the half.

(AP Photo/Aaron Doster)The New York Giants will be without starting quarterback Daniel Jones for Sunday’s game against the Seattle Seahawks. Jones was not expected to play because of a hamstring injury suffered last week against Cincinnati. Colt McCoy will make his first start of the season at QB for the Giants. Seattle was without both starting right tackle Brandon Shell (ankle) and backup Cedric Ogbuehi (calf) leaving a major question on the offensive line. ___CLEVELAND-TENNESSEEBrowns: WR Taywan Taylor, WR KhaDarel Hodge, CB Denzel Ward, RB Dontrell Hilliard, S Tedric Thompson, DE Joe Jackson.

(AP Photo/Chris Szagola)In this strangest of NFL seasons in this weirdest of years, here's a matchup of division leaders you wouldn't expect: Seattle hosting the New York Giants. “If you win your division, you win your division,” Carroll says, and he knows: Seattle went 7-9 in 2010 and won the NFC West, then beat New Orleans in a playoff game. Patrick Mahomes has thrown for at least 300 yards seven times this season and has 22 straight games with at least one TD passing. New England has won the past five meetings, including a 2018 divisional playoff game. Chargers WR Keenan Allen leads the NFL with 85 receptions and has a TD catch in five straight games.