Sam Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter to Justin Jefferson, and an attacking defense again fueled the Minnesota Vikings in a 23-17 victory over the San Francisco 49ers.

21 Pittsburgh sacked Louisville quarterback Malik Cunningham seven times in a 23-20 victory on Saturday. Pitt limited Louisville to 223 total yards — less than half of its season average coming in — and picked off Cunningham three times, including twice in the fourth quarter. Cunningham completed just 9 of 21 passes for 107 yards and a touchdown to go with three picks. Louisville running back Javian Hawkins scored on a 75-yard sprint but otherwise managed just 3 yards rushing on his other 12 attempts. BIG PICTURELouisville: The Cardinals were hoping to take another significant step forward in coach Scott Satterfield's second season.