HOUSTON – DeAndre Hopkins had 151 yards receiving, including a key reception in overtime, and Ka'imi Fairbairn's 36-yard field goal lifted the Houston Texans to a 19-16 win over the Dallas Cowboys on Sunday night.
The Cowboys got the ball first in OT but had to punt when Zach Cunningham stopped Ezekiel Elliott for no gain on third-and-1.
PHOTOS: Texans host Cowboys on SNF
A 49-yard catch and run by Hopkins got the Texans in scoring range in overtime. He grabbed a short pass from Watson and twice spun away from would-be tacklers to stretch the play.
Houston was just 1 of 5 in the red zone on Sunday with Fairbairn making four field goals to help the Texans to the victory.
WATCH: Houston Texans fans react to win
It is Houston's first win over the Cowboys (2-3) since the team's first game on Sept. 8, 2002, ending a three-game losing streak to Dallas. The Texans (2-3) did it in front of a franchise-record crowd of 72,008, which was peppered with plenty of Cowboys fans.
Deshaun Watson threw for 375 yards with a touchdown and an interception for the Texans, who won in overtime for the second straight week.
WATCH: Deshaun Watson talks about his performance
Dak Prescott had 208 yards passing and a touchdown but threw two interceptions for the Cowboys. Elliott, who entered the game as the NFL's leading rusher, was limited to 54 yards rushing.
The Texans were driving late in the fourth quarter when Xavier Woods intercepted Watson, who threw under heavy pressure, with 10 seconds left and returned it 15 yards to give Dallas the ball at its 47. Kareem Jackson nearly intercepted Prescott on the next play before his Hail Mary on the last play of regulation was knocked down in the end zone by receiver DeAndre Hopkins, who came in to play defense.
WATCH: Texas Coach Bill O'Brien postgame interview
A 27-yard pass interference call by Byron Jones on a ball intended for Hopkins got Houston to the 1-yard line in the third quarter. But two failed running plays followed by an incomplete pass forced another field goal which gave the Texans a 16-13 lead with about 8 1/2 minutes remaining.
The Cowboys tied it up on a 48-yard field goal with less than six minutes left. That drive was highlighted by a 44-yard pass by Prescott to Tavon Austin that he made after escaping sacks by J.J. Watt, Brandon Dunn and Zach Cunningham.
WATCH: JJ Watt postgame interview
Prescott's second interception came when Johnathan Joseph broke up a pass and rookie Justin Reid caught it just before it hit the turf in the third quarter. The Texans drove to the 3-yard line on the ensuing possession before the drive stalled and Fairbairn kicked a 21-yard field goal to tie it at 13-13.
Hopkins fumbled after a catch early in the third quarter and it was recovered by Jourdan Lewis and returned to the Houston 16. The Cowboys regained the lead when Prescott found Allen Hurns in the back of the end zone on a 3-yard touchdown pass that made it 13-10.
WATCH: DeAndre Hopkins talks beating the Cowboys
The Texans drove to the 2-yard line later in the second but Watson's pass on third down fell incomplete and they settled for a 20-yard field goal to push the lead to 10-6.
The Texans took their first lead when rookie Keke Coutee, who made his debut last week, scored on a 1-yard run early in the second quarter. Coutee celebrated his first career touchdown with a dance called the Shiggy Challenge from a Drake song called "In My Feelings" which includes the line: "Kiki do you love me?"
INJURIES
Houston RB Lamar Miller, who dealt with a chest injury this week, was active but did not play. ... Texans CB Kayvon Webster left the game in the first quarter with a quadriceps injury and didn't return.
UP NEXT
Cowboys: Host the Jacksonville Jaguars next Sunday.
Texans: Host the Buffalo Bills next Sunday.
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Some things to know about Sunday's game between the Cowboys and Texans:
IRVING'S RETURN
Defensive lineman David Irving is back for Dallas after starting the season on a four-game suspension for the second straight year. Irving had six sacks in his first four games coming off last year's suspension. He finished with seven sacks in eight games before a concussion sidelined him for the final four games.
The fourth-year player practiced this week for the first time since last November.
"We have a plan, but obviously when a player hasn't practiced football in a long time you just have to keep your eye on him and hopefully get some good work in," coach Jason Garrett said.
DYNAMIC DUO
Watt and Jadeveon Clowney led Houston's defense with dominant performances last week. Watt had two sacks, one tackle for loss, one quarterback hit and forced two fumbles against the Colts. Clowney added two sacks, four quarterback hits, four tackles for losses and a fumble recovery for a touchdown.
Watt has returned to form this season after playing just eight games over the previous two seasons because of back surgery and a broken leg. He's tied for first in the NFL with four forced fumbles and his five sacks are tied for second.
"Two elite players. They can really disrupt a game, can affect everything you are trying to do in the run game and the passing game," Garrett said. "Hard to block those guys one on one. You have to have a plan for them. Again, most teams have a plan for them and typically they show up anyway."
LAWRENCE LEADS
While Clowney and Watt have led Houston's defense, the Cowboys have one defensive end leading their group in DeMarcus Lawrence. He leads the NFL with 5 1/2 sacks and ranks second with eight tackles for losses. He's also recovered a fumble and has 21 tackles.
Houston coach Bill O'Brien raved about his work this season.
"Great length, athleticism. He plays very hard, plays hard on every snap," O'Brien said. "He's chasing the ball sideline to sideline, chasing the quarterback. He can wreck a game."
PROTECTING WATSON
Watson has been sacked 17 times, second most in the NFL. While Houston's offensive line has been criticized for the number of hits Watson has taken this season, he's quick to point out his lineman shouldn't take all the blame for the sacks.
"A lot of the sacks I put upon me getting rid of the ball or holding the ball too long or trying to create a play where I probably could have thrown the ball away or ran for extra yardage - two or three yards," he said. "But, those guys are doing a heck of a job and ... they're improving, building chemistry, enjoying the game, having fun and just getting better every week."