Jamies Winston passed for five touchdowns, New Orleans intercepted reigning NFL MVP Aaron Rodgers twice, and the Saints kicked off the post-Drew Brees era with a strikingly dominant opening 38-3 victory over the Green Bay Packers.

From the season-altering (Dak Prescott, Barkley) to the bizarre (Tyrod Taylor, Trent Brown), injuries are playing their traditionally significant role in the NFL. (AP Photo/Charles Rex Arbogast, File)ARLINGTON, Texas – From the season-altering to the bizarre, injuries are playing their traditionally significant role in the NFL. Brown also recently went back on the COVID-19 list, a newcomer among potential ailments with the NFL playing during a pandemic. Few teams have had the volume of injuries that have hit defending NFC champion San Francisco. New Orleans' star receiver, Michael Thomas, has had a tumultuous season in part because of ankle and hamstring injuries.

Arizona Cardinals quarterback Kyler Murray (1) runs in a touchdown against New York Jets free safety Marcus Maye (20) during the first half of an NFL football game, Sunday, Oct. 11, 2020, in East Rutherford. (AP Photo/Seth Wenig)EAST RUTHERFORD, N.J. – The Arizona Cardinals certainly came to the right place to get back on the winning track. Having Kyler Murray and the offense put up nearly 500 yards against the hapless and winless Jets was almost predictable. “I don’t want anyone on the team to feel satisfied with what happened today," said Murray, who threw for 380 yards. Jets: play at Miami next Sunday as NFL reorganizes schedule due to coronavirus pandemic.

Start with running back, where Giants star Saquon Barkley is believed to have torn the ACL in his right knee early in their loss at Chicago. The 49ers' Jimmy Garoppolo tried to play through a right ankle injury before Nick Mullens took over for the second half. Tevin Coleman also left San Francisco's win over the Jets with a late knee injury. Along with Lock and Sutton, the Broncos lost defensive end Dre'Mont Jones to a knee injury in their defeat at Pittsburgh. Washington guard Brandon Scherff, who left early in Arizona with a knee injury, was among the offensive linemen hurt around the NFL on Sunday.

It was a costly victory for San Francisco, which was already short-handed before losing Garoppolo to an ankle injury and Mostert to an injured knee. Defensive end Nick Bosa and defensive tackle Solomon Thomas were both carted off the field two plays apart with left knee injuries in the first quarter. Bosa was carted off the field with a left knee injury. Two plays later, Thomas needed to be carted off — also with a left knee injury —after an 8-yard reception by Chris Hogan. The drive was prolonged by a roughing-the-passer penalty on Henry Anderson when the Jets appeared to have stopped San Francisco on third-and-8.