Christian McCaffrey ran for the go-ahead touchdown with 7:54 to play, and the San Francisco 49ers beat the Los Angeles Chargers 22-16 in their first game back from a bye week.

Justin Herbert passed for three touchdowns and Tevaughn Campbell returned a Joe Mixon fumble 61 yards for a score, helping the Los Angeles Chargers hold off the Cincinnati Bengals for a 41-22 victory.

(AP Photo/AJ Mast)INDIANAPOLIS – Philip Rivers never flinched with the Indianapolis Colts facing a 21-0 first-half deficit Sunday. He went back to work and joined MVP quarterbacks Bert Jones and Peyton Manning in the Indianapolis Colts' record book. ... Mixon left in the first half with a right foot injury but returned at the start of the second half. ... DT Christian Covington and CB William Jackson III both got hurt in the second half and returned later. ... CB Xavier Rhodes and WR Marcus Johnson also were shaken up in the second half but returned.

The undefeated Titans are healing up from the NFL’s first COVID-19 outbreak. DeCastro will miss his third game of the season after sustaining an abdominal injury last week against Philadelphia. Johnson, Pittsburgh’s second-leading receiver, is out because of a back injury suffered on a punt return last week. Cincinnati also will be missing starting defensive tackle D.J. Eagles: RT Lane Johnson, WR DeSean Jackson, WR Alshon Jeffery, CB Avonte Maddox, S Marcus Epps, LB Duke Riley, QB Nate Sudfeld.