For Marcus Mariota, the loss of confidence was the biggest blow.

Trey Lance flashed his big arm in a brief preseason stint for San Francisco with a 76-yard TD pass to speedy rookie Danny Gray that helped the 49ers beat the Green Bay Packers 28-21.

Dallas star rookie linebacker Micah Parsons and Cincinnati running back Joe Mixon were the latest big-name players added to the COVID-19 reserve list.

Cincinnati sacks leader Trey Hendrickson and three other starters are among five Bengals that have been placed on the COVID-19 reserve list.

Cam Newton followed Mac Jones along the sideline, holding his right hand up, waiting for the rookie quarterback to slap it after the No. 15 overall pick threw a touchdown in a preseason game Sunday night.

(AP Photo/Bill Kostroun)SANTA CLARA, Calif. – Jimmy Garoppolo’s early NFL education came going up against Bill Belichick’s complicated defense each day in practice with the New England Patriots. Now Garoppolo gets his first chance to go up against his former coach and team since being traded away to San Francisco nearly three years ago when the 49ers visit the Patriots on Sunday. “It set me up for everything here, made the transition a lot easier,” Garoppolo said about the work he did with the Patriots. I’m glad that it’s worked out for him and San Francisco. “I think that’s one of the most impressive things about Jimmy,” Shanahan said.

(AP Photo/Jed Jacobsohn)SANTA CLARA, Calif. – A couple of unlikely players helped deliver the Philadelphia Eagles their first win of the season. Travis Fulgham caught a go-ahead 42-yard touchdown pass from Carson Wentz with 5:50 remaining and Alex Singleton returned an interception for a score to lift the Eagles to a 25-20 win over the San Francisco 49ers on Sunday night. But Fulgham got past backup cornerback Dontae Johnson and Wentz delivered a perfectly placed pass for the score that gave Philadelphia an 18-14 lead. It’s a resilient group.”TAKE IT AWAYThe Eagles got their first defensive takeaway of the season thanks to a poor decision by Mullens. With the Niners in the red zone, Mullens threw a ball up for grabs while under pressure and Rodney McLeod came up with it.