A son of former Sinaloa cartel leader Joaquin “El Chapo” Guzmán has pleaded not guilty in federal court in Chicago.

The United States has sanctioned a son of Mexican drug lord Joaquin “El Chapo” Guzman, three members of the Sinaloa cartel and two Mexican-based firms, alleging they trafficked fentanyl and other drugs into the U.S. Tuesday's sanctions came the day Mexican President Andrés Manuel López Obrador talked with President Joe Biden about immigration and the fentanyl crisis.

Prosecutors revealed in a recent indictment that while Sinaloa cartel boss Joaquín “El Chapo” Guzmán serves a life sentence, his sons have steered the family business into fentanyl, establishing a network of labs churning out massive quantities of the cheap, deadly drug that they smuggle into the U.S. The indictment unsealed April 14 in Manhattan details a generational shift.

She is the wife of Mexican drug kingpin Joaquin El Chapo Guzman and is accused of helping her husband run his multibillion-dollar cartel and plot his audacious escape from a Mexican prison in 2015. (Alexandria Adult Detention Center via AP)WASHINGTON – The wife of Mexican drug kingpin Joaquin “El Chapo” Guzman was arrested in the United States and accused of helping her husband run his multibillion-dollar cartel and plot his audacious escape from a Mexican prison in 2015. She is a dual citizen of the United States and Mexico. Her arrest is the latest twist in the bloody, multinational saga involving Guzman, the longtime head of the Sinaloa drug cartel. After Guzman was rearrested following his escape, Coronel lobbied the Mexican government to improve her husband’s prison conditions.