San Francisco 49ers coach Kyle Shanahan started training camp with a declaration that second-year player Trey Lance will be the starting quarterback and Jimmy Garoppolo will be moving on soon.

James Conner ran for two touchdowns and caught a 45-yard TD pass from backup quarterback Colt McCoy as the short-handed Arizona Cardinals beat the San Francisco 49ers 31-17.

It was a costly victory for San Francisco, which was already short-handed before losing Garoppolo to an ankle injury and Mostert to an injured knee. Defensive end Nick Bosa and defensive tackle Solomon Thomas were both carted off the field two plays apart with left knee injuries in the first quarter. Bosa was carted off the field with a left knee injury. Two plays later, Thomas needed to be carted off — also with a left knee injury —after an 8-yard reception by Chris Hogan. The drive was prolonged by a roughing-the-passer penalty on Henry Anderson when the Jets appeared to have stopped San Francisco on third-and-8.