Patrick Mahomes threw for 360 yards and five touchdowns, lifting the Kansas City Chiefs to an impressive 44-21 road win over the Arizona Cardinals in the opener for both teams.

Patrick Mahomes threw his first two touchdown passes in nearly a month, Clyde Edwards-Helaire added two more scores on the ground, and the Kansas City Chiefs forced five turnovers in rolling to a record-setting 48-9 victory over the Las Vegas Raiders.

Justin Herbert threw for three touchdowns, Austin Ekeler rushed for 117 yards and scored twice and the Los Angeles Chargers knocked the Las Vegas Raiders from the unbeaten ranks with a 28-14 victory.

Reigning AFC Special Teams Player of the Week Daniel Carlson’s 22-yard field goal as time expired in overtime lifted the Las Vegas Raiders to a 31-28 victory over the Miami Dolphins.

Indianapolis Colts cornerback Isaiah Rodgers (34) jumps over Las Vegas Raiders fullback Alec Ingold (45) during the first half of an NFL football game, Sunday, Dec. 13, 2020, in Las Vegas. (AP Photo/Isaac Brekken)LAS VEGAS – Frank Reich found himself regularly amazed while he watched everything his Indianapolis Colts accomplished in their first trip to Sin City. He also marveled at the breakaway speed of Jonathan Taylor, who outran the Raiders' entire secondary on a 62-yard TD sprint. Hilton caught two touchdown passes from Philip Rivers, while Taylor rushed for a career-best 150 yards and two scores. A touchdown-saving tackle by Vegas' Trayvon Mullen with 1 second left in the first half limited the Colts' halftime lead to 20-14.